Objective Interstitial lung disease (ILD) is the leading cause of morbidity and mortality in systemic sclerosis (SSc) patients. We aimed to investigate the impact of sex on SSc-ILD. Methods EUSTAR SSc patients with radiologically confirmed ILD and available percentage predicted forced vital capacity (%pFVC) were included. Demographics and disease features were recorded. A change in %pFVC over 12 months (s.d. 6) (cohort 1) was classified into stable (<= 4%), mild (5-9%) and large progression (>= 10%). In those with 2-year longitudinal %pFVC (cohort 2), the %pFVC change at each 12-month (s.d. 6) interval was calculated. Logistic regression analyses [odds ratio (OR) and 95% CI] and Cox proportional hazards models adjusted for age and %pFVC were applied. Results A total of 1136 male and 5253 female SSc-ILD patients were identified. Males were significantly younger, had a shorter disease duration, had a higher prevalence of CRP elevation and frequently had diffuse cutaneous involvement. In cohort 1 (1655 females and 390 males), a higher percentage of males had stable ILD (74.4% vs 69.4%, P = 0.056). In multivariable analysis, disease duration and %pFVC [OR 0.99 (95% CI 0.98, 0.99) and OR 0.97 (95% CI 0.95, 0.99), respectively] in males and age, %pFVC and anti-centromere [OR 1.02 (95% CI 1.00, 1.04), OR 0.97 (95% CI 0.96, 0.98) and OR 0.39 (95% CI 0.245, 0.63), respectively] in females were associated with large progression. The 1-year mortality rate was higher in males (5.1% vs 2.5%, P = 0.013). In cohort 2 (849 females and 209 males), a higher percentage of females showed periods of large progression (11.7% vs 7.7%, P = 0.023), the percentage of patients with none, one or two periods of worsening was not different. The overall death rate was 30.9% for males and 20.4% in females (P < 0.001). In the survival analysis, male sex was a predictor of mortality [OR 1.95 (95% CI 1.66, 2.28)]. Conclusions Male SSc-ILD patients have a poorer prognosis and sex-specific predictors exist in SSc-ILD.
Sex influence on outcomes of patients with systemic sclerosis–associated interstitial lung disease: a EUSTAR database analysis / Campochiaro, Corrado; Hoffmann-Vold, Anna-Maria; Avouac, Jerome; Henes, Jörg; de Vries-Bouwstra, Jeska; Smith, Vanessa; Siegert, Elise; Airò, Paolo; Oksel, Fahrettin; Pellerito, Raffaele; Vanthuyne, Marie; Pozzi, Maria Rosa; Inanc, Murat; Sibilia, Jean; Gabrielli, Armando; Distler, Oliver; Allanore, Yannick; Cerinic, Marco Matucci; Walker, Ulrich; Iannone, Florenzo; Becvar, Radim; Cuomo, Giovanna; Montecucco, C; Carreira, Patricia E; Iudici, Michele; Kucharz, Eugene J; Zanatta, Elisabetta; Bancel, Pr Dominique Farge; Hesselstrand, Roger; Balbir-Gurman, Alexandra; Pellerito, Raffaele; Bertoldo, Eugenia; Damjanov, Nemanja; Granollers, Vera Ortiz-Santamaria; Heitmann, Stefan; Salvador, Maria João; Stamenkovic, Bojana; Selmi, Carlo Francesco; Herrick, Ariane; ller-Ladner, Ulf Mü; Engelhart, Merete; Riccieri, Valeria; Ionescu, Ruxandra Maria; Gheorghiu, Ana Maria; Sunderkötter, Cord; Distler, Jörg; Ingegnoli, Francesca; Mouthon, Luc; Cantatore, Francesco Paolo; Ullman, Susanne; Wiland, Piotr; Vanthuyne, Marie; Saar, Petra; Herrmann, Kristine; De Langhe, Ellen; Mayer, Miroslav; Yavuz, Sule; de Souza Müller, Carolina; Zenone, Thierry; Vacca, Alessandra; Solanki, Kamal; Rosato, Edoardo; Yargucu, Fahrettin Oksel Figen; Tanaseanu, Cristina-Mihaela; Foti, Rosario; Furst, Daniel E; Adler, Peter Villiger Sabine; Martín, Jorge Juan González; Litinsky, Ira; Del Galdo, Francesco; Seskute, Goda; Saketkoo, Lesley Ann; Kerzberg, Eduardo; Castellví, Ivan; Spertini, François; Hsu, Vivien M; Martin, Thierry; Schmeiser, Tim; Majewski, Dominik; Bernardino, Vera; Puttini, Piercarlo Sarzi; Moroncini, Gianluca; Stork, Jiri; Hachulla, Eric; de la Pena Lefebvre, Paloma Garcıa; Limonta, Massimiliano; Sfikakis, Petros; Cutolo, Maurizio; Ananieva, Lidia P; Czirjak, Laszlo; Denton, Christopher; De Luca, Giacomo; Dagna, Lorenzo; Null, Null. - In: RHEUMATOLOGY. - ISSN 1462-0324. - 62:7(2023), pp. 2483-2491. [10.1093/rheumatology/keac660]
Sex influence on outcomes of patients with systemic sclerosis–associated interstitial lung disease: a EUSTAR database analysis
Rosato, EdoardoMembro del Collaboration Group
;
2023
Abstract
Objective Interstitial lung disease (ILD) is the leading cause of morbidity and mortality in systemic sclerosis (SSc) patients. We aimed to investigate the impact of sex on SSc-ILD. Methods EUSTAR SSc patients with radiologically confirmed ILD and available percentage predicted forced vital capacity (%pFVC) were included. Demographics and disease features were recorded. A change in %pFVC over 12 months (s.d. 6) (cohort 1) was classified into stable (<= 4%), mild (5-9%) and large progression (>= 10%). In those with 2-year longitudinal %pFVC (cohort 2), the %pFVC change at each 12-month (s.d. 6) interval was calculated. Logistic regression analyses [odds ratio (OR) and 95% CI] and Cox proportional hazards models adjusted for age and %pFVC were applied. Results A total of 1136 male and 5253 female SSc-ILD patients were identified. Males were significantly younger, had a shorter disease duration, had a higher prevalence of CRP elevation and frequently had diffuse cutaneous involvement. In cohort 1 (1655 females and 390 males), a higher percentage of males had stable ILD (74.4% vs 69.4%, P = 0.056). In multivariable analysis, disease duration and %pFVC [OR 0.99 (95% CI 0.98, 0.99) and OR 0.97 (95% CI 0.95, 0.99), respectively] in males and age, %pFVC and anti-centromere [OR 1.02 (95% CI 1.00, 1.04), OR 0.97 (95% CI 0.96, 0.98) and OR 0.39 (95% CI 0.245, 0.63), respectively] in females were associated with large progression. The 1-year mortality rate was higher in males (5.1% vs 2.5%, P = 0.013). In cohort 2 (849 females and 209 males), a higher percentage of females showed periods of large progression (11.7% vs 7.7%, P = 0.023), the percentage of patients with none, one or two periods of worsening was not different. The overall death rate was 30.9% for males and 20.4% in females (P < 0.001). In the survival analysis, male sex was a predictor of mortality [OR 1.95 (95% CI 1.66, 2.28)]. Conclusions Male SSc-ILD patients have a poorer prognosis and sex-specific predictors exist in SSc-ILD.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
